Drug interactions
Etodolac + Vorapaxar
Severity: Major
Etodolac and Vorapaxar: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is an antiplatelet agent with significant bleeding risk, and NSAIDs add to it by impairing platelet function and irritating the gastric mucosa.
What this interaction means in plain words
Etodolac and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Vorapaxar blocks PAR-1 thrombin receptors on platelets while etodolac inhibits COX-1-dependent platelet aggregation, giving additive antiplatelet effects.
What to do
Avoid regular NSAID use with vorapaxar where possible and use paracetamol for analgesia. If needed, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Etopan XL 600 mg Film-coated prolonged release tablets - SmPC sections 4.3/4.5 (class statement: Anti-platelet agents; "Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): Increased risk of gastrointestinal bleeding (see section 4.4).") — electronic medicines compendium (UK SmPC)
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Vorapaxar?
MediHelp rates the interaction as major. Etodolac and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is an antiplatelet agent with significant bleeding risk, and NSAIDs add to it by impairing platelet function and irritating the gastric mucosa.
How serious is the interaction between Etodolac and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with vorapaxar where possible and use paracetamol for analgesia. If needed, consider gastroprotection and monitor for bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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