Drug interactions
Etodolac + Willow bark
Severity: Moderate
Etodolac and Willow bark: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylic acid, so taking it with etodolac duplicates NSAID-type effects. This can increase the risk of gastrointestinal irritation, bleeding, and renal effects.
What this interaction means in plain words
Etodolac and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition from salicylate formation, plus possible renal tubular competition.
What to do
Avoid using willow bark with etodolac. If both have been taken, monitor for gastrointestinal bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Willow bark?
MediHelp rates the interaction as moderate. Etodolac and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Willow bark contains salicin, which is converted to salicylic acid, so taking it with etodolac duplicates NSAID-type effects. This can increase the risk of gastrointestinal irritation, bleeding, and renal effects.
How serious is the interaction between Etodolac and Willow bark?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using willow bark with etodolac. If both have been taken, monitor for gastrointestinal bleeding and renal function.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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