Drug interactions
Etoposide + Isavuconazonium
Severity: Moderate
Etoposide and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and may raise etoposide levels, contributing to greater toxicity. The legacy direction of effect is unlikely, as etoposide is not a meaningful CYP3A4 inhibitor.
What this interaction means in plain words
Etoposide and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4, decreasing etoposide metabolism.
What to do
Monitor blood counts and etoposide toxicity, and reduce the etoposide dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Etoposide with Isavuconazonium?
MediHelp rates the interaction as moderate. Etoposide and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and may raise etoposide levels, contributing to greater toxicity. The legacy direction of effect is unlikely, as etoposide is not a meaningful CYP3A4 inhibitor.
How serious is the interaction between Etoposide and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and etoposide toxicity, and reduce the etoposide dose if adverse effects emerge.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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