Drug interactions
Etoposide + Lemborexant
Severity: Minor
Etoposide and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide may weakly inhibit CYP3A4 and increase lemborexant exposure, causing more next-day somnolence. The effect is expected to be modest.
What this interaction means in plain words
Etoposide and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Lemborexant belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition reducing lemborexant clearance.
What to do
Monitor for excessive sedation and use the lowest effective lemborexant dose, with a lower maximum dose if a CYP3A inhibitor is confirmed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Etoposide with Lemborexant?
MediHelp rates the interaction as minor. Etoposide and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etoposide may weakly inhibit CYP3A4 and increase lemborexant exposure, causing more next-day somnolence. The effect is expected to be modest.
How serious is the interaction between Etoposide and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and use the lowest effective lemborexant dose, with a lower maximum dose if a CYP3A inhibitor is confirmed.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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