Drug interactions
Etoposide + Quinidine
Severity: Moderate
Etoposide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and may increase etoposide exposure, which could worsen myelosuppression and gastrointestinal toxicity. Clinical data are limited.
What this interaction means in plain words
Etoposide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein efflux of etoposide by quinidine.
What to do
Monitor blood counts and toxicity during combined therapy, and reduce the etoposide dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Quinidine?
MediHelp rates the interaction as moderate. Etoposide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-glycoprotein and may increase etoposide exposure, which could worsen myelosuppression and gastrointestinal toxicity. Clinical data are limited.
How serious is the interaction between Etoposide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and toxicity during combined therapy, and reduce the etoposide dose if toxicity appears.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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