Drug interactions
Etoposide + Secobarbital
Severity: Moderate
Etoposide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing barbiturates may increase etoposide clearance and reduce exposure, possibly lessening its antitumour effect. Evidence is mainly from related anticonvulsant inducers.
What this interaction means in plain words
Etoposide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by secobarbital increases etoposide metabolism.
What to do
Use a non-inducing sedative where possible. Monitor treatment response and consider dose adjustments if the combination is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Secobarbital?
MediHelp rates the interaction as moderate. Etoposide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing barbiturates may increase etoposide clearance and reduce exposure, possibly lessening its antitumour effect. Evidence is mainly from related anticonvulsant inducers.
How serious is the interaction between Etoposide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing sedative where possible. Monitor treatment response and consider dose adjustments if the combination is required.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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