Drug interactions
Etoposide + Verapamil
Severity: Moderate
Etoposide and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and can increase etoposide cellular accumulation and exposure. This may enhance myelosuppression and mucositis. Verapamil has been studied as a resistance modulator for etoposide.
What this interaction means in plain words
Etoposide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-glycoprotein efflux of etoposide, and may also reduce CYP3A4-mediated clearance.
What to do
Monitor complete blood counts closely. Reduce the etoposide dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Verapamil?
MediHelp rates the interaction as moderate. Etoposide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein and can increase etoposide cellular accumulation and exposure. This may enhance myelosuppression and mucositis. Verapamil has been studied as a resistance modulator for etoposide.
How serious is the interaction between Etoposide and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely. Reduce the etoposide dose if marked myelosuppression occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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