Drug interactions
Etoposide + Voxelotor
Severity: Moderate
Etoposide and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 in vitro and increases exposure to sensitive CYP3A4 substrates. Etoposide is partly CYP3A4-metabolised, so levels may rise modestly, but etoposide is not a sensitive substrate and the clinical effect is uncertain.
What this interaction means in plain words
Etoposide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, which may reduce the metabolism of etoposide.
What to do
Monitor blood counts and signs of etoposide toxicity during co-administration. Reduce the etoposide dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Etoposide with Voxelotor?
MediHelp rates the interaction as moderate. Etoposide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 in vitro and increases exposure to sensitive CYP3A4 substrates. Etoposide is partly CYP3A4-metabolised, so levels may rise modestly, but etoposide is not a sensitive substrate and the clinical effect is uncertain.
How serious is the interaction between Etoposide and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of etoposide toxicity during co-administration. Reduce the etoposide dose if marked myelosuppression occurs.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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