Drug interactions
Etoposide + Warfarin
Severity: Moderate
Etoposide and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
INR elevations and bleeding have been reported when etoposide is given to patients on warfarin. Chemotherapy-related thrombocytopenia, poor nutrition and liver changes make the response hard to predict.
What this interaction means in plain words
Etoposide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not well established; it may combine altered warfarin metabolism or protein binding with chemotherapy-induced thrombocytopenia and reduced vitamin K intake.
What to do
Monitor INR and platelet counts frequently during each chemotherapy cycle and adjust warfarin as needed. Consider low-molecular-weight heparin if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Warfarin?
MediHelp rates the interaction as moderate. Etoposide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. INR elevations and bleeding have been reported when etoposide is given to patients on warfarin. Chemotherapy-related thrombocytopenia, poor nutrition and liver changes make the response hard to predict.
How serious is the interaction between Etoposide and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and platelet counts frequently during each chemotherapy cycle and adjust warfarin as needed. Consider low-molecular-weight heparin if control is unstable.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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