Drug interactions
Etrasimod + Fludarabine
Severity: Major
Etrasimod and Fludarabine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes by sequestering them in lymphoid tissue, and fludarabine causes marked lymphopenia. Together they could cause additive immunosuppression and serious infection, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Fludarabine belongs to Oncology.
Why it happens
Additive lymphocyte reduction: S1P receptor modulation with purine analog cytotoxicity.
What to do
Avoid combining them, and allow an adequate interval after stopping etrasimod before starting fludarabine. If unavoidable, monitor lymphocyte counts and for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Belatacept + Fludarabine Major
- Dengue vaccine + Fludarabine Major
- Fingolimod + Fludarabine Major
- Fludarabine + Ofatumumab sc Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Fludarabine?
MediHelp rates the interaction as major. Etrasimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes by sequestering them in lymphoid tissue, and fludarabine causes marked lymphopenia. Together they could cause additive immunosuppression and serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Fludarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them, and allow an adequate interval after stopping etrasimod before starting fludarabine. If unavoidable, monitor lymphocyte counts and for infection.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
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