Drug interactions
Etrasimod + Letrozole
Severity: Minor
Etrasimod and Letrozole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and may increase infection risk. Letrozole is an aromatase inhibitor without meaningful immunosuppressive activity, so an additive effect is not expected.
What this interaction means in plain words
Etrasimod and Letrozole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etrasimod belongs to Gastrointestinal Tract; Letrozole belongs to Oncology.
Why it happens
No established mechanism; letrozole is not meaningfully immunosuppressive.
What to do
No change is routinely needed. Monitor for infection and follow etrasimod lymphocyte monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etrasimod and Letrozole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Letrozole
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Letrozole?
MediHelp rates the interaction as minor. Etrasimod and Letrozole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod lowers circulating lymphocytes and may increase infection risk. Letrozole is an aromatase inhibitor without meaningful immunosuppressive activity, so an additive effect is not expected.
How serious is the interaction between Etrasimod and Letrozole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is routinely needed. Monitor for infection and follow etrasimod lymphocyte monitoring.
What other medicines interact with Letrozole?
MediHelp also lists interactions of Letrozole with, for example, Desogestrel-ethinyl estradiol, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Letrozole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
