Drug interactions
Etrasimod + Nilotinib
Severity: Moderate
Etrasimod and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is cleared by several CYP enzymes including CYP2C8, CYP2C9 and CYP3A4, and nilotinib inhibits some of these enzymes, which may increase etrasimod exposure. Both drugs also have immune-modulating effects, so combined use may increase infection risk.
What this interaction means in plain words
Etrasimod and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Possible inhibition of etrasimod metabolism by nilotinib plus additive immunosuppressive effects.
What to do
Avoid combining where possible. If used together, monitor for infection and for bradycardia or other etrasimod adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Nilotinib?
MediHelp rates the interaction as moderate. Etrasimod and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod is cleared by several CYP enzymes including CYP2C8, CYP2C9 and CYP3A4, and nilotinib inhibits some of these enzymes, which may increase etrasimod exposure. Both drugs also have immune-modulating effects, so combined use may increase infection risk.
How serious is the interaction between Etrasimod and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, monitor for infection and for bradycardia or other etrasimod adverse effects.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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