Drug interactions
Etrasimod + Pimavanserin
Severity: Moderate
Etrasimod and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin prolongs the QT interval, while etrasimod can cause transient bradycardia and AV conduction delay at initiation. Bradycardia is a risk factor for torsades de pointes, so the combination may raise arrhythmia risk.
What this interaction means in plain words
Etrasimod and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: QT prolongation with etrasimod-induced bradycardia.
What to do
Obtain a baseline ECG and consider cardiology advice before starting etrasimod in patients on pimavanserin. Monitor heart rate and QTc, and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Pimavanserin?
MediHelp rates the interaction as moderate. Etrasimod and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin prolongs the QT interval, while etrasimod can cause transient bradycardia and AV conduction delay at initiation. Bradycardia is a risk factor for torsades de pointes, so the combination may raise arrhythmia risk.
How serious is the interaction between Etrasimod and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and consider cardiology advice before starting etrasimod in patients on pimavanserin. Monitor heart rate and QTc, and correct potassium and magnesium.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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