Drug interactions
Etrasimod + Propranolol
Severity: Moderate
Etrasimod and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and delay AV conduction when started. Stable beta-blocker therapy did not show additive heart rate effects, but starting a beta blocker in a patient on etrasimod has not been well studied.
What this interaction means in plain words
Etrasimod and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Propranolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects of S1P receptor modulation and beta blockade.
What to do
Monitor heart rate and ECG when starting etrasimod in patients on propranolol, and be cautious when adding a beta blocker to stable etrasimod. Follow labeling for patients with conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Propranolol?
MediHelp rates the interaction as moderate. Etrasimod and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and delay AV conduction when started. Stable beta-blocker therapy did not show additive heart rate effects, but starting a beta blocker in a patient on etrasimod has not been well studied.
How serious is the interaction between Etrasimod and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting etrasimod in patients on propranolol, and be cautious when adding a beta blocker to stable etrasimod. Follow labeling for patients with conduction disease.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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