Drug interactions
Etrasimod + Sunitinib
Severity: Major
Etrasimod and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is a sphingosine 1-phosphate receptor modulator that reduces circulating lymphocytes, and sunitinib is a myelosuppressive antineoplastic. Together they may add to immunosuppression and the risk of infection, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Sunitinib belongs to Oncology.
Why it happens
Additive immunosuppressive effects from lymphocyte sequestration and antineoplastic myelosuppression.
What to do
Avoid the combination where possible. If both are required, monitor blood counts and watch closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Sunitinib?
MediHelp rates the interaction as major. Etrasimod and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod is a sphingosine 1-phosphate receptor modulator that reduces circulating lymphocytes, and sunitinib is a myelosuppressive antineoplastic. Together they may add to immunosuppression and the risk of infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor blood counts and watch closely for infection.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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