Drug interactions
Etrasimod + Timolol
Severity: Moderate
Etrasimod and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently lower heart rate and slow AV conduction when started. Beta-blockers also slow the heart rate and conduction, so additive bradycardia or AV block is possible, particularly if the beta-blocker is started after etrasimod.
What this interaction means in plain words
Etrasimod and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Timolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects from S1P receptor modulation and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG when initiating etrasimod in a patient taking timolol, and when adding a beta-blocker to stable etrasimod. Seek cardiology advice for patients with pre-existing conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etrasimod and Timolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Timolol?
MediHelp rates the interaction as moderate. Etrasimod and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently lower heart rate and slow AV conduction when started. Beta-blockers also slow the heart rate and conduction, so additive bradycardia or AV block is possible, particularly if the beta-blocker is started after etrasimod.
How serious is the interaction between Etrasimod and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when initiating etrasimod in a patient taking timolol, and when adding a beta-blocker to stable etrasimod. Seek cardiology advice for patients with pre-existing conduction disease.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
