Drug interactions
Etrasimod + Trastuzumab
Severity: Moderate
Etrasimod and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocyte counts, and trastuzumab is an antineoplastic that can add to immune compromise. Combined use has not been formally studied, but infection risk could be additive. The effect of etrasimod on lymphocytes may persist for some weeks after it is stopped.
What this interaction means in plain words
Etrasimod and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppression from etrasimod-induced lymphocyte sequestration plus the effects of antineoplastic therapy.
What to do
Avoid starting etrasimod during trastuzumab therapy where an alternative exists. If both are needed, monitor for infection and check blood counts regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Trastuzumab?
MediHelp rates the interaction as moderate. Etrasimod and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod lowers circulating lymphocyte counts, and trastuzumab is an antineoplastic that can add to immune compromise. Combined use has not been formally studied, but infection risk could be additive. The effect of etrasimod on lymphocytes may persist for some weeks after it is stopped.
How serious is the interaction between Etrasimod and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting etrasimod during trastuzumab therapy where an alternative exists. If both are needed, monitor for infection and check blood counts regularly.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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