Drug interactions
Etrasimod + Tretinoin
Severity: Moderate
Etrasimod and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes, and tretinoin used for oncology can add to immune and marrow effects. The combination has not been studied and may raise infection risk, which can persist after etrasimod is stopped.
What this interaction means in plain words
Etrasimod and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Tretinoin belongs to Dermatology.
Why it happens
Potential additive immunosuppression from sphingosine-1-phosphate receptor modulation and the effects of tretinoin therapy.
What to do
Avoid combining where possible, or monitor lymphocyte and blood counts and watch for infection. Consider the persisting effects of etrasimod for some weeks after it is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Tretinoin?
MediHelp rates the interaction as moderate. Etrasimod and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod reduces circulating lymphocytes, and tretinoin used for oncology can add to immune and marrow effects. The combination has not been studied and may raise infection risk, which can persist after etrasimod is stopped.
How serious is the interaction between Etrasimod and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor lymphocyte and blood counts and watch for infection. Consider the persisting effects of etrasimod for some weeks after it is stopped.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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