Drug interactions
Etynodiol + Mifepristone
Severity: Moderate
Etynodiol and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone blocks progesterone receptors and may counteract the effect of the progestin in etynodiol-containing contraceptives. This could reduce contraceptive reliability or disturb cycle control. Reliable contraception is particularly important because mifepristone is a pregnancy-terminating agent.
What this interaction means in plain words
Etynodiol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mifepristone is a progesterone receptor antagonist and opposes the progestogenic effect of etynodiol.
What to do
Use a non-hormonal backup contraceptive method during mifepristone treatment and for a period afterward. Review the contraceptive choice with the patient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Etynodiol with Mifepristone?
MediHelp rates the interaction as moderate. Etynodiol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone blocks progesterone receptors and may counteract the effect of the progestin in etynodiol-containing contraceptives. This could reduce contraceptive reliability or disturb cycle control. Reliable contraception is particularly important because mifepristone is a pregnancy-terminating agent.
How serious is the interaction between Etynodiol and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal backup contraceptive method during mifepristone treatment and for a period afterward. Review the contraceptive choice with the patient.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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