Drug interactions
Exemestane + Mifepristone
Severity: Minor
Exemestane and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise exemestane concentrations through CYP3A4 inhibition, but exemestane has a wide safety margin and clinically important effects are unlikely.
What this interaction means in plain words
Exemestane and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exemestane belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces exemestane metabolism.
What to do
No dose adjustment is needed; monitor for usual exemestane adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Exemestane
Frequently asked questions
Can I take Exemestane with Mifepristone?
MediHelp rates the interaction as minor. Exemestane and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may raise exemestane concentrations through CYP3A4 inhibition, but exemestane has a wide safety margin and clinically important effects are unlikely.
How serious is the interaction between Exemestane and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for usual exemestane adverse effects.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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