Drug interactions
Exemestane + Secobarbital
Severity: Moderate
Exemestane and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and lower exemestane levels, potentially reducing its estrogen-suppressing effect. Labeling advises a higher exemestane dose with potent CYP3A4 inducers.
What this interaction means in plain words
Exemestane and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction by secobarbital increases exemestane clearance.
What to do
Consider increasing exemestane to 50 mg daily after a meal while the inducer is used. Return to the standard dose after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Exemestane
Frequently asked questions
Can I take Exemestane with Secobarbital?
MediHelp rates the interaction as moderate. Exemestane and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may induce CYP3A4 and lower exemestane levels, potentially reducing its estrogen-suppressing effect. Labeling advises a higher exemestane dose with potent CYP3A4 inducers.
How serious is the interaction between Exemestane and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing exemestane to 50 mg daily after a meal while the inducer is used. Return to the standard dose after the inducer is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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