Drug interactions
Exenatide + Tolbutamide
Severity: Moderate
Exenatide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide combined with a sulfonylurea increases the risk of hypoglycemia, which can be significant. This is a labeled interaction.
What this interaction means in plain words
Exenatide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exenatide belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive pharmacodynamics: exenatide enhances glucose-dependent insulin secretion and tolbutamide stimulates insulin release independent of glucose.
What to do
Consider lowering the tolbutamide dose when starting exenatide. Monitor blood glucose and educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Exenatide with Tolbutamide?
MediHelp rates the interaction as moderate. Exenatide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide combined with a sulfonylurea increases the risk of hypoglycemia, which can be significant. This is a labeled interaction.
How serious is the interaction between Exenatide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the tolbutamide dose when starting exenatide. Monitor blood glucose and educate the patient about hypoglycemia.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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