Drug interactions
Exenatide + Warfarin
Severity: Moderate
Exenatide and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Post-marketing reports describe increased INR and bleeding events in patients who started exenatide while taking warfarin. The causal relationship is not firmly established, but the anticoagulant effect of warfarin may be intensified.
What this interaction means in plain words
Exenatide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exenatide belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not established; altered absorption, changes in oral intake or other indirect effects have been proposed.
What to do
Check INR more often when exenatide is started or stopped in a patient on warfarin. Adjust the warfarin dose according to INR results and watch for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Exenatide with Warfarin?
MediHelp rates the interaction as moderate. Exenatide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Post-marketing reports describe increased INR and bleeding events in patients who started exenatide while taking warfarin. The causal relationship is not firmly established, but the anticoagulant effect of warfarin may be intensified.
How serious is the interaction between Exenatide and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often when exenatide is started or stopped in a patient on warfarin. Adjust the warfarin dose according to INR results and watch for signs of bleeding.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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