Drug interactions
Exenatide injectable + Fosinopril-hydrochlorothiazide
Severity: Minor
Exenatide injectable and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can impair glucose tolerance and may reduce the glucose-lowering effect of exenatide. The effect is usually modest but can worsen glycemic control.
What this interaction means in plain words
Exenatide injectable and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-related reduced insulin sensitivity and secretion, partly via hypokalemia, opposes antidiabetic effect.
What to do
Monitor glycemic control when starting, stopping or changing the thiazide dose, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Exenatide injectable with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Exenatide injectable and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides can impair glucose tolerance and may reduce the glucose-lowering effect of exenatide. The effect is usually modest but can worsen glycemic control.
How serious is the interaction between Exenatide injectable and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting, stopping or changing the thiazide dose, and adjust antidiabetic therapy if needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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