Drug interactions
Exenatide injectable + Prednisone
Severity: Moderate
Exenatide injectable and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone raises blood glucose and opposes the glucose-lowering action of exenatide. Glycemic control may worsen, particularly with higher or prolonged steroid doses.
What this interaction means in plain words
Exenatide injectable and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids cause insulin resistance and increased hepatic gluconeogenesis, pharmacodynamically opposing antidiabetic effects.
What to do
Monitor blood glucose more frequently during steroid therapy and after dose changes. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Exenatide injectable with Prednisone?
MediHelp rates the interaction as moderate. Exenatide injectable and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone raises blood glucose and opposes the glucose-lowering action of exenatide. Glycemic control may worsen, particularly with higher or prolonged steroid doses.
How serious is the interaction between Exenatide injectable and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during steroid therapy and after dose changes. Adjust antidiabetic therapy as needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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