Drug interactions
Exenatide injectable + Tolazamide
Severity: Moderate
Exenatide injectable and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide improves glucose-dependent insulin secretion, and when it is added to a sulfonylurea the glucose-lowering effect is additive. This raises the likelihood of hypoglycemia, particularly when treatment starts or doses are increased.
What this interaction means in plain words
Exenatide injectable and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from GLP-1 receptor agonism plus sulfonylurea-driven insulin release.
What to do
Consider reducing the tolazamide dose when exenatide is started and monitor blood glucose. Teach the patient to recognize and treat hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Exenatide injectable with Tolazamide?
MediHelp rates the interaction as moderate. Exenatide injectable and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide improves glucose-dependent insulin secretion, and when it is added to a sulfonylurea the glucose-lowering effect is additive. This raises the likelihood of hypoglycemia, particularly when treatment starts or doses are increased.
How serious is the interaction between Exenatide injectable and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose when exenatide is started and monitor blood glucose. Teach the patient to recognize and treat hypoglycemia.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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