Drug interactions
Exenatide injectable + Tolbutamide
Severity: Moderate
Exenatide injectable and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide increases glucose-dependent insulin secretion, and with sulfonylureas the risk of hypoglycemia is increased. This was observed in clinical trials.
What this interaction means in plain words
Exenatide injectable and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive stimulation of insulin secretion by the GLP-1 agonist and the sulfonylurea.
What to do
Consider reducing the tolbutamide dose when starting exenatide. Monitor blood glucose and educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Exenatide injectable with Tolbutamide?
MediHelp rates the interaction as moderate. Exenatide injectable and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide increases glucose-dependent insulin secretion, and with sulfonylureas the risk of hypoglycemia is increased. This was observed in clinical trials.
How serious is the interaction between Exenatide injectable and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolbutamide dose when starting exenatide. Monitor blood glucose and educate the patient about hypoglycemia.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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