Drug interactions
Exenatide injectable + Warfarin
Severity: Moderate
Exenatide injectable and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Postmarketing reports describe increased INR, sometimes with bleeding, in patients on warfarin who started exenatide. The cause is unclear, though reduced food intake and weight change may contribute.
What this interaction means in plain words
Exenatide injectable and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not established; possible effects of altered appetite, vitamin K intake and gastric emptying.
What to do
Check INR more frequently after starting exenatide and adjust warfarin dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Exenatide injectable with Warfarin?
MediHelp rates the interaction as moderate. Exenatide injectable and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Postmarketing reports describe increased INR, sometimes with bleeding, in patients on warfarin who started exenatide. The cause is unclear, though reduced food intake and weight change may contribute.
How serious is the interaction between Exenatide injectable and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more frequently after starting exenatide and adjust warfarin dose as required.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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