Drug interactions
Exenatide subdermal implant + Warfarin
Severity: Moderate
Exenatide subdermal implant and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Increased INR with exenatide has been reported in warfarin-treated patients, sometimes with bleeding. The implant provides continuous exposure, so the same concern applies.
What this interaction means in plain words
Exenatide subdermal implant and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not established; possible effects of reduced intake and delayed gastric emptying.
What to do
Monitor INR after implant placement and removal, and adjust warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Exenatide subdermal implant with Warfarin?
MediHelp rates the interaction as moderate. Exenatide subdermal implant and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Increased INR with exenatide has been reported in warfarin-treated patients, sometimes with bleeding. The implant provides continuous exposure, so the same concern applies.
How serious is the interaction between Exenatide subdermal implant and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR after implant placement and removal, and adjust warfarin dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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