Drug interactions
Ezogabine + Foscarnet
Severity: Major
Ezogabine and Foscarnet: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can cause QT prolongation, and foscarnet can also prolong QT and disturb electrolytes. Using both increases the likelihood of QT-related arrhythmia.
What this interaction means in plain words
Ezogabine and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Foscarnet belongs to Anti Virals.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes and correct any deficits. Avoid the combination in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Foscarnet?
MediHelp rates the interaction as major. Ezogabine and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine can cause QT prolongation, and foscarnet can also prolong QT and disturb electrolytes. Using both increases the likelihood of QT-related arrhythmia.
How serious is the interaction between Ezogabine and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and correct any deficits. Avoid the combination in patients with other QT risk factors.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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