Drug interactions
Ezogabine + Glasdegib
Severity: Major
Ezogabine and Glasdegib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QTc interval, and ezogabine may have a similar effect. Together they may increase the risk of torsades de pointes and other arrhythmias.
What this interaction means in plain words
Ezogabine and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Glasdegib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Avoid the combination where possible. If it must be used, check ECG and electrolytes at baseline and periodically, and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ezogabine
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Ezogabine with Glasdegib?
MediHelp rates the interaction as major. Ezogabine and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib can prolong the QTc interval, and ezogabine may have a similar effect. Together they may increase the risk of torsades de pointes and other arrhythmias.
How serious is the interaction between Ezogabine and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it must be used, check ECG and electrolytes at baseline and periodically, and correct hypokalemia and hypomagnesemia.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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