Drug interactions
Ezogabine + Ivosidenib
Severity: Major
Ezogabine and Ivosidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QTc interval, and ezogabine may add to this effect. The combination raises the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Ezogabine and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Avoid the combination or substitute another antiseizure drug. If unavoidable, monitor ECG and electrolytes more frequently and interrupt or reduce ivosidenib for significant QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ezogabine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ezogabine with Ivosidenib?
MediHelp rates the interaction as major. Ezogabine and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib can prolong the QTc interval, and ezogabine may add to this effect. The combination raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Ezogabine and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or substitute another antiseizure drug. If unavoidable, monitor ECG and electrolytes more frequently and interrupt or reduce ivosidenib for significant QTc prolongation.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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