Drug interactions
Ezogabine + Lefamulin
Severity: Major
Ezogabine and Lefamulin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and ezogabine may have a similar effect. Combined use may increase the risk of ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Ezogabine and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Avoid the combination if another antibiotic is suitable. If both are required, monitor ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ezogabine
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Ezogabine with Lefamulin?
MediHelp rates the interaction as major. Ezogabine and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin can prolong the QT interval, and ezogabine may have a similar effect. Combined use may increase the risk of ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Ezogabine and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if another antibiotic is suitable. If both are required, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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