Drug interactions
Ezogabine + Methadone
Severity: Major
Ezogabine and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT interval prolongation, and methadone also prolongs QT, so combined use may increase arrhythmia risk. Ezogabine has been withdrawn from the market in many regions.
What this interaction means in plain words
Ezogabine and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain a baseline ECG and monitor QTc, potassium and magnesium if the combination cannot be avoided. Prefer an alternative anticonvulsant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Methadone?
MediHelp rates the interaction as major. Ezogabine and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine has been associated with QT interval prolongation, and methadone also prolongs QT, so combined use may increase arrhythmia risk. Ezogabine has been withdrawn from the market in many regions.
How serious is the interaction between Ezogabine and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, potassium and magnesium if the combination cannot be avoided. Prefer an alternative anticonvulsant.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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