Drug interactions
Ezogabine + Nortriptyline
Severity: Moderate
Ezogabine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and nortriptyline can add to this effect. Ezogabine can also cause urinary retention, which tricyclic anticholinergic activity may worsen.
What this interaction means in plain words
Ezogabine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with additive urinary retention from anticholinergic effects.
What to do
Monitor the ECG at baseline and during dose titration, and watch for urinary retention. Correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Nortriptyline?
MediHelp rates the interaction as moderate. Ezogabine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and nortriptyline can add to this effect. Ezogabine can also cause urinary retention, which tricyclic anticholinergic activity may worsen.
How serious is the interaction between Ezogabine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG at baseline and during dose titration, and watch for urinary retention. Correct electrolyte disturbances.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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