Drug interactions
Ezogabine + Pazopanib
Severity: Moderate
Ezogabine and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes, and ezogabine can modestly lengthen the QT interval. Using them together may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Ezogabine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and repeat the ECG periodically during co-therapy. Reduce or stop pazopanib or reconsider ezogabine if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Ezogabine with Pazopanib?
MediHelp rates the interaction as moderate. Ezogabine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is associated with QT prolongation and torsades de pointes, and ezogabine can modestly lengthen the QT interval. Using them together may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Ezogabine and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat the ECG periodically during co-therapy. Reduce or stop pazopanib or reconsider ezogabine if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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