Drug interactions
Ezogabine + Sunitinib
Severity: Moderate
Ezogabine and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is associated with QT prolongation and torsades de pointes, and ezogabine can add a modest QT effect. The combination may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Ezogabine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and electrolytes and monitor the QTc periodically during co-therapy. Reduce or interrupt sunitinib or reconsider ezogabine if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Ezogabine with Sunitinib?
MediHelp rates the interaction as moderate. Ezogabine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib is associated with QT prolongation and torsades de pointes, and ezogabine can add a modest QT effect. The combination may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Ezogabine and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor the QTc periodically during co-therapy. Reduce or interrupt sunitinib or reconsider ezogabine if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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