Drug interactions
Famciclovir + Tenofovir df
Severity: Moderate
Famciclovir and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penciclovir, the active metabolite of famciclovir, and tenofovir are both cleared renally including tubular secretion. Co-administration may raise levels of either drug, and tenofovir adds nephrotoxic potential.
What this interaction means in plain words
Famciclovir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and possible additive renal effects.
What to do
Monitor serum creatinine and phosphate periodically. Adjust the famciclovir dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famciclovir
Frequently asked questions
Can I take Famciclovir with Tenofovir df?
MediHelp rates the interaction as moderate. Famciclovir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penciclovir, the active metabolite of famciclovir, and tenofovir are both cleared renally including tubular secretion. Co-administration may raise levels of either drug, and tenofovir adds nephrotoxic potential.
How serious is the interaction between Famciclovir and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and phosphate periodically. Adjust the famciclovir dose to renal function.
What other medicines interact with Famciclovir?
MediHelp also lists interactions of Famciclovir with, for example, Talimogene laherparepvec, Varicella virus vaccine live, Zoster vaccine live. The full list is on the Famciclovir page.
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