Drug interactions
Digoxin + Famciclovir
Severity: Minor
Digoxin and Famciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famciclovir modestly increases peak digoxin concentrations, with no meaningful change in overall exposure. The effect is small and rarely clinically significant.
What this interaction means in plain words
Digoxin and Famciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Famciclovir belongs to Anti Virals.
Why it happens
Mechanism not established; possible effect on digoxin transport or absorption.
What to do
No dose change is needed routinely. Monitor digoxin levels and toxicity symptoms in patients with narrow margins or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famciclovir
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Famciclovir?
MediHelp rates the interaction as minor. Digoxin and Famciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famciclovir modestly increases peak digoxin concentrations, with no meaningful change in overall exposure. The effect is small and rarely clinically significant.
How serious is the interaction between Digoxin and Famciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor digoxin levels and toxicity symptoms in patients with narrow margins or renal impairment.
What other medicines interact with Famciclovir?
MediHelp also lists interactions of Famciclovir with, for example, Talimogene laherparepvec, Varicella virus vaccine live, Zoster vaccine live. The full list is on the Famciclovir page.
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