Drug interactions
Famciclovir + Probenecid
Severity: Minor
Famciclovir and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal secretion of penciclovir, the active metabolite of famciclovir, increasing its plasma levels. The change is usually modest and rarely requires action.
What this interaction means in plain words
Famciclovir and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famciclovir belongs to Anti Virals; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular organic anion transport, reducing penciclovir elimination.
What to do
No routine dose adjustment is needed. Monitor for adverse effects such as headache or nausea, and in renal impairment consider dose reduction per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Famciclovir
Frequently asked questions
Can I take Famciclovir with Probenecid?
MediHelp rates the interaction as minor. Famciclovir and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid reduces the renal secretion of penciclovir, the active metabolite of famciclovir, increasing its plasma levels. The change is usually modest and rarely requires action.
How serious is the interaction between Famciclovir and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for adverse effects such as headache or nausea, and in renal impairment consider dose reduction per labeling.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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