Drug interactions
Famotidine + Indinavir
Severity: Moderate
Famotidine and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir needs an acidic stomach for optimal absorption. Famotidine raises gastric pH and may reduce indinavir concentrations, risking reduced antiviral efficacy and resistance.
What this interaction means in plain words
Famotidine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH decreases the pH-dependent dissolution and absorption of indinavir.
What to do
Monitor virologic response and consider an alternative to acid suppression; if used, take indinavir at least 1 hour before the H2 blocker or consider a boosted regimen per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Famotidine and Indinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Indinavir?
MediHelp rates the interaction as moderate. Famotidine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir needs an acidic stomach for optimal absorption. Famotidine raises gastric pH and may reduce indinavir concentrations, risking reduced antiviral efficacy and resistance.
How serious is the interaction between Famotidine and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor virologic response and consider an alternative to acid suppression; if used, take indinavir at least 1 hour before the H2 blocker or consider a boosted regimen per labeling.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
