Drug interactions
Famotidine + Ledipasvir / sofosbuvir
Severity: Moderate
Famotidine and Ledipasvir / sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir dissolves less at higher pH, so acid-reducing drugs can lower its exposure and risk reducing hepatitis C cure rates. H2 blockers are acceptable at limited doses.
What this interaction means in plain words
Famotidine and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces ledipasvir solubility and absorption.
What to do
Give famotidine simultaneously with or 12 hours apart from ledipasvir/sofosbuvir, keeping doses to no more than 40 mg twice daily. Higher doses need review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Ledipasvir / sofosbuvir?
MediHelp rates the interaction as moderate. Famotidine and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir dissolves less at higher pH, so acid-reducing drugs can lower its exposure and risk reducing hepatitis C cure rates. H2 blockers are acceptable at limited doses.
How serious is the interaction between Famotidine and Ledipasvir / sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give famotidine simultaneously with or 12 hours apart from ledipasvir/sofosbuvir, keeping doses to no more than 40 mg twice daily. Higher doses need review.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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