Drug interactions
Famotidine + Metformin-sitagliptin
Severity: Minor
Famotidine and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may modestly raise metformin exposure by reducing its renal tubular secretion. The change is generally small and rarely clinically significant at usual doses.
What this interaction means in plain words
Famotidine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Competition for renal tubular secretion via organic cation transporters such as OCT2 and MATE.
What to do
No dose change is usually needed; be more attentive to metformin adverse effects if renal function is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Famotidine and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Famotidine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may modestly raise metformin exposure by reducing its renal tubular secretion. The change is generally small and rarely clinically significant at usual doses.
How serious is the interaction between Famotidine and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; be more attentive to metformin adverse effects if renal function is impaired.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
