Drug interactions
Famotidine + Mycophenolate
Severity: Minor
Famotidine and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression can reduce absorption of mycophenolate mofetil, lowering mycophenolic acid exposure. The clinical effect on rejection is variable and generally modest.
What this interaction means in plain words
Famotidine and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher gastric pH reduces dissolution and absorption of mycophenolate mofetil.
What to do
No routine change is needed. Watch for signs of reduced immunosuppression in high-risk transplant patients, with mycophenolic acid level monitoring if available.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Mycophenolate?
MediHelp rates the interaction as minor. Famotidine and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression can reduce absorption of mycophenolate mofetil, lowering mycophenolic acid exposure. The clinical effect on rejection is variable and generally modest.
How serious is the interaction between Famotidine and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for signs of reduced immunosuppression in high-risk transplant patients, with mycophenolic acid level monitoring if available.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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