Drug interactions
Famotidine + Pimozide
Severity: Moderate
Famotidine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide strongly prolongs the QT interval, and famotidine has been linked to QT prolongation, mainly with renal impairment. Combined use may add to the risk of torsades de pointes.
What this interaction means in plain words
Famotidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; famotidine does not meaningfully inhibit CYP3A4.
What to do
Monitor ECG and electrolytes, and adjust famotidine dose in renal impairment. Avoid in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Famotidine with Pimozide?
MediHelp rates the interaction as moderate. Famotidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide strongly prolongs the QT interval, and famotidine has been linked to QT prolongation, mainly with renal impairment. Combined use may add to the risk of torsades de pointes.
How serious is the interaction between Famotidine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and adjust famotidine dose in renal impairment. Avoid in patients with other QT risk factors.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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