Drug interactions
Famotidine + Saquinavir
Severity: Minor
Famotidine and Saquinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine has been reported to modestly raise saquinavir exposure, probably by changing absorption. This is not considered clinically important.
What this interaction means in plain words
Famotidine and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not established, possibly altered absorption from higher gastric pH.
What to do
No dose change is needed. Monitor for saquinavir adverse effects such as GI upset or QT effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Saquinavir?
MediHelp rates the interaction as minor. Famotidine and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine has been reported to modestly raise saquinavir exposure, probably by changing absorption. This is not considered clinically important.
How serious is the interaction between Famotidine and Saquinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for saquinavir adverse effects such as GI upset or QT effects.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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