Drug interactions
Famotidine + Sofosbuvir / velpatasvir
Severity: Moderate
Famotidine and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir dissolves poorly at higher pH, so acid suppression can lower its exposure and potentially reduce hepatitis C cure rates. The effect with low-dose H2 blockers is modest.
What this interaction means in plain words
Famotidine and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH decreases the pH-dependent solubility and absorption of velpatasvir.
What to do
Give famotidine simultaneously with or 12 hours apart from sofosbuvir/velpatasvir, not exceeding 40 mg twice daily. Avoid higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Famotidine and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir dissolves poorly at higher pH, so acid suppression can lower its exposure and potentially reduce hepatitis C cure rates. The effect with low-dose H2 blockers is modest.
How serious is the interaction between Famotidine and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give famotidine simultaneously with or 12 hours apart from sofosbuvir/velpatasvir, not exceeding 40 mg twice daily. Avoid higher doses.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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