Drug interactions
Felodipine + Fexinidazole
Severity: Moderate
Felodipine and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites can inhibit CYP3A4, which is the main route of felodipine clearance. Felodipine exposure may rise, causing excessive vasodilation, hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Felodipine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated felodipine metabolism by fexinidazole, raising felodipine plasma concentrations.
What to do
Monitor blood pressure and heart rate during the short fexinidazole course and reduce the felodipine dose if hypotension or edema develops. Consider a temporary alternative antihypertensive if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Fexinidazole?
MediHelp rates the interaction as moderate. Felodipine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites can inhibit CYP3A4, which is the main route of felodipine clearance. Felodipine exposure may rise, causing excessive vasodilation, hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Felodipine and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the short fexinidazole course and reduce the felodipine dose if hypotension or edema develops. Consider a temporary alternative antihypertensive if needed.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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