Drug interactions
Felodipine + Fosamprenavir
Severity: Moderate
Felodipine and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, whose active metabolite amprenavir is a CYP3A4 inhibitor (more so with ritonavir), can raise felodipine levels. This may cause pronounced hypotension, edema and tachycardia.
What this interaction means in plain words
Felodipine and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4-mediated felodipine metabolism.
What to do
Monitor blood pressure and edema, and begin felodipine at a low dose with downward adjustment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Fosamprenavir?
MediHelp rates the interaction as moderate. Felodipine and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, whose active metabolite amprenavir is a CYP3A4 inhibitor (more so with ritonavir), can raise felodipine levels. This may cause pronounced hypotension, edema and tachycardia.
How serious is the interaction between Felodipine and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and begin felodipine at a low dose with downward adjustment if needed.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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