Drug interactions
Felodipine + Hydrocortisone
Severity: Minor
Felodipine and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may modestly lower felodipine concentrations through CYP3A4 induction, potentially reducing blood pressure control. Felodipine is also a weak P-glycoprotein inhibitor, but the effect on hydrocortisone is probably small.
What this interaction means in plain words
Felodipine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by hydrocortisone lowers felodipine metabolism-dependent exposure; minor P-gp inhibition by felodipine.
What to do
Monitor blood pressure when starting or stopping high-dose hydrocortisone and adjust the felodipine dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Hydrocortisone?
MediHelp rates the interaction as minor. Felodipine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may modestly lower felodipine concentrations through CYP3A4 induction, potentially reducing blood pressure control. Felodipine is also a weak P-glycoprotein inhibitor, but the effect on hydrocortisone is probably small.
How serious is the interaction between Felodipine and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping high-dose hydrocortisone and adjust the felodipine dose if control changes.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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